Why does fat expand differently in distinct body regions? This study identifies GPC3 as regional depot-specific obesity responsive gene that selectively promotes the expansion of inguinal, but not epididymal, white adipose tissue in mice fed a high fat diet.
Citation: Li Y, Tao M, Ibáñez CF, Xie M (2026) Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity. PLoS Biol 24(3):
e3003700.
https://doi.org/10.1371/journal.pbio.300370… [+77000 chars]
