Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

Author summary We have used cryo-electron microscopy and solution biophysical techniques to understand the structure of the Rep protein from a Redondovirus, a CRESS DNA virus originally found in human respiratory samples. The small circular Rep-encoding singl…

Abstract Circular Rep-encoding single-stranded DNA (CRESS-DNA) virus Rep proteins are multidomain enzymes that mediate viral DNA rolling-circle replication. Reps nick viral DNA to expose a 3 end for… [+103420 chars]
Structures of nucleotide-bound Redondovirus Rep protein link conformation and function - FHMnews