Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples [RESEARCH]

Confounding factors in assessing the enriched expression of somatic mutant alleles in bulk tumor samples [RESEARCH]

Allele-specific expression (ASE) of somatic mutations can be caused by cis-activation of the mutant allele or silencing of the wild-type allele and has been investigated by examining the enrichment of mutant allele in RNA relative to DNA. Here we show that th…

Allele-specific expression (ASE) of somatic mutations can be caused by cis-activation of the mutant allele or silencing of the wild-type allele and has been investigated by examining the enrichment … [+1695 chars]