Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes

Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes

Bioisosteric replacement of benzenes with caged hydrocarbons can form enhanced lead compounds with improved drug-like properties, but synthetic challenges limit their application. Now, a collective strategy for synthesizing saturated bioisosteres of 1,2,4-tri…

  • Meanwell, N. A. Improving drug design: an update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in nontraditional drug space. Chem. Res… [+20109 chars]

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