Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data

Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data

Background Systemic sclerosis–associated interstitial lung disease (SSc-ILD) is a major clinical challenge with no effective treatments. It is also the leading cause of death in patients with systemic sclerosis. Thus, understanding its underlying molecular me…

1. Introduction Systemic sclerosis (SSc) is a rare autoimmune disease, which is characterized by skin and organ fibrosis and vascular injury [1,2]. Interstitial lung disease (ILD) is a common clinic… [+62870 chars]
Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data - FHMnews