Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis

Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis

Chromoanasynthesis is an elusive form of complex chromosomal rearrangement commonly detected in cancer and congenital disorder. Here, the authors develop a long-read DNA sequencing approach and show that chromoanasynthesis is generated by microhomology-mediat…

  • Krupina, K., Goginashvili, A. & Cleveland, D. W. Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements. Nat. Rev. Genet.25, 196210 (2024). Google Scho… [+14661 chars]

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    Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis - FHMnews