Multi-strategy engineering of transaminase enables a one-pot synergistic biocatalytic cascade to a key florfenicol chiral intermediate

Multi-strategy engineering of transaminase enables a one-pot synergistic biocatalytic cascade to a key florfenicol chiral intermediate

Green Chem., 2026, Accepted ManuscriptDOI: 10.1039/D5GC06908D, PaperHong-Ru Zhao, Wen-Tao Shen, Bingmei Su, Lian Xu, Juan Lin(1R,2R)-2-Amino-1-(4-(methylsulfonyl)phenyl)propane-1,3-diol [(1R,2R)-3] is a key chiral intermediate for the antibiotic florfenicol. …

(1R,2R)-2-Amino-1-(4-(methylsulfonyl)phenyl)propane-1,3-diol [(1R,2R)-3] is a key chiral intermediate for the antibiotic florfenicol. Its asymmetric synthesis remains challenging due to the difficult… [+1870 chars]

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Multi-strategy engineering of transaminase enables a one-pot synergistic biocatalytic cascade to a key florfenicol chiral intermediate - FHMnews