Optical control of the cardiac rhythm with photoswitchable NaV1.5 channel blockers

Optical control of the cardiac rhythm with photoswitchable NaV1.5 channel blockers

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of NaV1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

  • Chen, L., He, Y., Wang, X., Ge, J. & Li, H. Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation. Clin. Transl. Med.11, e530 (2021). Goo… [+11050 chars]

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    Optical control of the cardiac rhythm with photoswitchable NaV1.5 channel blockers - FHMnews