Single-engineered-residue solvation perturbations regulate global protein architecture and function

Single-engineered-residue solvation perturbations regulate global protein architecture and function

By engineering single residue of protein with a light-switchable molecule, this study reveals that local hydrophobicity propagates through hydrogen bond network to reshape protein structure and function, shifting the paradigm to structure–hydration– function.

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    Single-engineered-residue solvation perturbations regulate global protein architecture and function - FHMnews