Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system

Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system

Bacteria employ diverse nucleases to defend against viruses. Here, authors characterize Upx, a single-protein, dual-nuclease system, and reveal that a specific phage protein relieves auto-inhibition to activate its antiviral function.

  • Yirmiya, E. et al. Phages overcome bacterial immunity via diverse anti-defence proteins. Nature625, 352359 (2024). Google Scholar 
  • Antine, S. P. et al. Structural basis of Gabija anti-… [+5871 chars]

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    Structural and mechanistic insights into the dual-nuclease defense protein Upx as an anti-phage system - FHMnews