Structural basis of RNA-guided transcription by a dCas12f–σE–RNAP complex

Structural basis of RNA-guided transcription by a dCas12f–σE–RNAP complex

Cryogenic electron microscopy reveals how dCas12f with σE recruits RNAP to targeted DNA, initiating transcription at a fixed downstream distance, bypassing canonical −35 recognition and stabilizing the −10 element in an unusual manner.

  • Wiegand, T. et al. TnpB homologues exapted from transposons are RNA-guided transcription factors. Nature631, 439448 (2024). Article  ADS  PubMed  PubMed Central  CAS  Google Scholar  <… [+15511 chars]

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