AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design

AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design

Author summary Coronaviruses pose a constant threat to global health due to the potential transmission from animal to human hosts. Vaccine development has been limited by the instability of the coronavirus spike protein in the prefusion state and since future…

Citation: Melchers JM, Juraszek J, Hulswit RJ, van Overveld D, Le L, van Kuppeveld FJ, et al. (2026) AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal em… [+60035 chars]

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AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design - FHMnews