Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Animal experiments All animal work in this study was approved by the Animal Care Committee of The Centre for Phenogenomics (TCP) (AUP 25-0100H) and by the Institutional Animal Care and Use Committee… [+35408 chars]