Assessment of references for the quantitative analysis of LINE-1 and Alu methylation in cellular DNA and circulating cell-free DNA of cancer patients

Assessment of references for the quantitative analysis of LINE-1 and Alu methylation in cellular DNA and circulating cell-free DNA of cancer patients

The LINE-1 and Alu retrotransposon elements, with more than 90% of their sequences being methylated, contribute to 30% of the human genome. Their hypomethylation profile, representing global methylation in cellular and cell-free DNA (cfDNA) from cancer, has b…

Abstract The LINE-1 and Alu retrotransposon elements, with more than 90% of their sequences being methylated, contribute to 30% of the human genome. Their hypomethylation profile, representing globa… [+50734 chars]

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Assessment of references for the quantitative analysis of LINE-1 and Alu methylation in cellular DNA and circulating cell-free DNA of cancer patients - FHMnews