Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity

NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.

Sex as a biological variable In consideration of the clinical context, in which TNBC71, ANRE72,73 and their co-occurrence73,74 are predominantly observed in female patients, we have proactively chos… [+41972 chars]